Author

S. Mahmud

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#graph neural networks Open access Sep 2026

Computational screening of oncogenic genetic variations in tumor suppressor proteins driving gastric cancer pathogenesis

Gastric cancer (GC) is currently the fifth most common cancer globally, often driven by dysregulation of tumor suppressor pathways. While individual studies on genetic variations of proteins are common, a comprehensive systems-level analysis of proteins regulating GC pathways showing both expression dysregulation and h...

Faria Ferdouse Mim, Taslima Akter Sumiya, Roksana Khanam et al. · PLoS ONE · 0 citations

Open access Aug 2026

Functional annotation of PBK missense SNPs and dysregulation in multiple myeloma: A bioinformatics approach integrating identification of natural inhibitors

T-LAK cell-originated protein kinase (PBK/TOPK) is a serine/threonine kinase that is essential for DNA damage repair, cell division, mitosis, and tumor growth. Deleterious missense single nucleotide polymorphisms (nsSNPs) may alter the biological activity of PBK and structural stability, thus contributing to cancer pro...

Fahmida Tabassum, Roksana Khanam, Md. Shakil Ahamed et al. · Journal of Genetic Engineeri... · 0 citations