Author

S. Maione

3 papers indexed here

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Open access Nov 2026

Anterior insular cortex neurostimulation modulates sensory hypersensitivity and pain-related emotional behaviors in a rat model of chronic neuropathic pain.

BACKGROUND AND AIMS Chronic neuropathic pain (NP) is frequently accompanied by anxiety- and depression-like behaviors that contribute to functional impairment. The insular cortex plays a central role in pain processing and interoceptive regulation, with the anterior insular cortex (AIC) critically involved in integrati...

R. M. Acunha, Priscila Medeiros, H. Machado et al. · Physiology and Behavior · 0 citations

Open access Oct 2026

Adolescent social isolation drives sex-dependent shifts in medial prefrontal cortex endocannabinoid tone and excitatory/inhibitory balance: the protective role of a methyl donor.

Prolonged social isolation triggers neuropsychiatric impairments linked to brain neurotransmitter imbalances. This study investigated the impact of social isolation on sensory perception, affective states, and the levels of amino acid neurotransmitters and endocannabinoids within the medial prefrontal cortex (mPFC) of...

Federica Ricciardi, Laura Mosca, C. Belardo et al. · Neuropharmacology · 0 citations

Open access Sep 2026

Locus Coeruleus mediates the pharmacological effects of 2-Pentadecyl-2-oxazoline in a mouse model of neuropathic pain.

A chemogenetic approach is employed to chronically silence LC noradrenergic neurons in a male mouse model of neuropathic pain induced by spared nerve injury and results suggest a therapeutic relevance of C15OXA in neuropathic pain and support a possible involvement of the LC in mediating its behavioral and molecular ef...

F. Ricciardi, M. Llorca-Torralba, L. Luongo et al. · Neuropharmacology · 0 citations