SUMMARY Pseudokinase domains (PsKDs) mediate key signaling processes involved in human disease. Despite transformative success in targeting catalytically active protein kinases, drug development for pseudokinases has lagged behind. Although they lack catalytic activity, pseudokinases are conformationally dynamic and ar...
Joshua B. Sheetz, Yuko Tsutsui, Kumar D. Ashtekar et al.· Structure· 0 citations
Mutations in Leucine-Rich Repeat Kinase 2 (LRRK2) are the second most common cause of autosomal-dominant Parkinson’s disease (PD), and increased LRRK2 kinase activity is also observed in idiopathic PD, making LRRK2 a major actionable therapeutic target. LRRK2 is a 286-kDa multidomain enzyme containing a Ras-like GTPase...
Amalia Villagran Suarez, Kathryn S. Hatch, Tatyana Bodrug et al.· bioRxiv· 1 citation
It is shown that PRF functions as a regulatory signal that rewires host translation in favor of viral replication, highlighting PRF as a stress-inducing module that enhances viral replication.
Audrey Xavier, Melinda Kolling, Ashley M. Bourke et al.· Cell· 0 citations
A unified framework for understanding LRRK2 regulation with broad therapeutic implications is provided, showing that the ROC GTPase governs switching between autoinhibited and active states: GTP binding promotes activation, whereas GDP binding enforces autoinhibition.
Amalia Villagran Suarez, Kathryn S. Hatch, Tatyana Bodrug et al.· Cell· 0 citations
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