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Author

S. Meinke

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Open access Oct 2026

T-BET promotes inflammatory specialization without driving terminal maturation of iPSC-derived NK cells

Induced pluripotent stem cells (iPSCs) provide a scalable platform for off-the-shelf immune cell therapies; however, the mechanisms controlling maturation and functional specialization of iPSC-derived natural killer (iNK) cells are not fully understood. In this study, we combined single-cell transcriptomics, phenotyp...

C. Marsal, Muhammad Kashif, Sophia Borate et al. · 0 citations
Open access Jul 2026

Extracellular vesicle secretome from mesenchymal stromal cells prevents post-ischemic heart failure by targeting cardiac fibrosis.

A clinically approved PDGFRβ-targeted PET-imaging platform for longitudinal assessment of fibrotic activity in STEMI patients and preliminary observations suggest that myofibroblast activation persists for up to 2 months after STEMI in selected patients establish a translational therapeutic-diagnostic framework for ind...

Karl-Henrik Grinnemo, Ken Braesch-Andersen, Johan O. Wedin et al. · 1 citation
Open access Aug 2026

Oncolytic HSV1716 attenuates tumor-killing activity of infected primary NK cells

It is demonstrated that primary human NK cells are infected by HSV1716 and undergo functional and phenotypic changes, leading to a diminished cytotoxic capacity.

K. Susek, D. Holla, C. Marsal et al. · 0 citations

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