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Open access Aug 2026

Pre-treatment polyfunctionality percentage (PFA) of CD8+ T cells is associated with development of immune-related adverse events (irAEs) in patients receiving immune checkpoint inhibitors (ICIs)

Introduction Immune checkpoint inhibitors (ICIs) have improved cancer survival, but immune-related adverse events (irAEs) occur frequently and can have devastating consequences. There are no validated methods to evaluate risk of irAEs prior to initiation of ICIs. Materials and Methods We conducted a pilot study evaluat...

Jonathan Thompson, Katie A. Palen, S. Menon et al. · 0 citations

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