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Author

S. Messing

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2 papers indexed here

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Open access Oct 2026

Molecular mechanism of KRAS binding to BRAF and its regulation by the BRAF-specific region

Although the RBD engages KRAS through a conserved mechanism, the BRAF(CRD) adopts a hinge-like displacement away from KRAS, forming fewer contacts and contributing less to binding than CRAF(CRD).

D. Bonsor, Suzanne I. Sandin Lawrence, Timothy H. Tran et al. · 0 citations
Open access Sep 2026

Structural mechanisms underlying resistance to Switch-II pocket inhibitors in KRAS

Direct targeting of KRAS through the Switch-II pocket is an effective therapeutic strategy, but acquired resistance limits clinical benefit. We examine clinically observed resistance mutations (R68S, H95Q, Y96C, Y96D and Q99L) arising during KRAS G12C inhibitor therapy using biochemical, structural, computational and c...

M. J. Whitley, M. Dyba, Mayukh Chakrabarti et al. · 0 citations

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