Author

S. Mohanty

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Open access Oct 2026

The Gαi/o GPCR LPAR2 Acts as a Non-Classical Factor for Aldosterone Induced Injury in a Cardiomyocyte Model

Aldosterone is a key regulator of systemic sodium, potassium, and fluid homeostasis. Chronic elevation of aldosterone, as observed in primary aldosteronism, chronic heart and kidney diseases, promotes cardiac hypertrophy, inflammation, fibrosis, and heart failure, which are further enhanced in aging. Although these pat...

S. Mohanty, Ru-Jun Gong, Marc Tatar · bioRxiv · 0 citations

Open access Jul 2026

HPRC2: A human pangenome reference with near-complete coverage of common genetic variation

The Human Pangenome Reference Consortium’s (HPRC) Release 2 (HPRC2) is presented, an openly available, second phase pangenome that is an approximately fivefold expansion in genome number over HPRC Release 1 (HPRC1) and measurable improvement in genome completeness, contiguity, and accuracy.

Julian K. Lucas, Prajna Hebbar, Wen-Wei Liao et al. · bioRxiv · 6 citations