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Open access Aug 2026

Reverse Transcriptase Connection and RNase H Domain Variation in HIV-1 Subtype C Among Individuals with Virologic Failure in Botswana

Background: Classical reverse transcriptase (RT) drug resistance mutations (DRMs) are primary determinants of antiretroviral treatment failure, but polymorphisms within the RT connection and RNase H domains may also influence RT inhibitor susceptibility. These regions remain poorly characterised in HIV-1 subtype C (HIV...

Boitumelo J. L. Zuze, W. Choga, Natasha O. Moraka-Mankge et al. · 0 citations
Review Open access Sep 2026

Targeted point-of-care HIV testing at birth for newborns at high risk of vertical transmission in Botswana: a prospective cohort study.

BACKGROUND HIV testing at birth supports timely infant HIV diagnosis and treatment. We evaluated the operational feasibility and effectiveness of facility-based, risk-stratified birth testing for newborns at high risk and moderate risk of vertical HIV transmission in Botswana. METHODS We tested newborns at high risk...

G. Ajibola, S. Brummel, Terence Mohammed et al. · 0 citations

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