S. Nadella

Abstract B020: Myofibroblasts induce neuroplasticity to promote pancreatic inflammation and cancer progression

Pancreatic ductal adenocarcinoma (PDAC) co-opts the peripheral nervous system through nerve hypertrophy, axonogenesis, and perineural invasion; these processes correlate with patient morbidity and mortality. Prior work has shown that autonomic nerves directly modulate neoplastic cells in PDAC, but whether cancer-asso...