Author

S. Narayan

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Open access Oct 2026

Tissue-Specific Deletion of FKBP51 Reveals Distinct Roles in Stress Responsivity and Metabolic Regulation.

The co-chaperone FKBP51 serves as a critical molecular intersection between environmental stress and metabolic health, yet the specific tissue-level mechanisms driving its systemic effects remain poorly understood. While global FKBP51 deficiency provides robust protection against diet-induced obesity and insulin resist...

M. Springer, L. Brix, V. Kovářová et al. · Molecular Metabolism · 0 citations

Open access Aug 2026

Multilevel sex-influenced neurobiological signatures of early life adversity

This work emphasizes the necessity of considering sex when investigating developmental and neurobiological underpinnings of stress-related disorders and displays a vast range of lasting effects of developmental stress on the brain, which provides a valuable resource for future studies aiming to improve psychiatric trea...

S. Narayan, C. Beer, V. Kovářová et al. · Proceedings of the National... · 0 citations

Open access Aug 2026

Mineralocorticoid receptor signaling in GABAergic neurons regulates stress-induced cognitive flexibility

These findings suggest that MRs in GABAergic neurons normally function as critical constraints on excitatory synaptic plasticity during high-stress states, underscoring that adaptive stress responses rely on a finely tuned, cell-type-specific balance of corticosteroid signaling within limbic microcircuits.

Huanqing Yang, V. Kovářová, Alena O. Godunova et al. · Neurobiology of Stress · 0 citations