Author

S. Nierkens

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Review Open access Sep 2026

TAMing the tumor: targeting immune inhibitory receptors on tumor-associated macrophages in pediatric brain tumors – an emerging immunotherapy strategy

Abstract Brain tumors are the most common solid tumors in children. Despite recent advancements in cancer survival, the prognosis for high-grade pediatric brain tumors remains poor, with treatments resulting in severe long-term side effects. Over the last decade, immune checkpoint blockade (ICB) has emerged as a promis...

Lieke Mooij, J. Meesters-Ensing, F. Calkoen et al. · Journal for ImmunoTherapy of... · 0 citations

Open access Sep 2026

Persistent IL-18 fuels expansion of CD38+HLA-DR+CD8+ T cells in Still's disease and macrophage activation syndrome.

CD38+HLA-DR+CD8+ T cells are identified as a potential mechanistic link between Still's disease and MAS and highlight this subset as a candidate therapeutic target.

Greta Rogani, R. Erkens, A. Bodelón et al. · Arthritis & Rheumatology · 0 citations

Open access Aug 2026

Spatial multi-omics reveals targetable immunosuppressive macrophage T-cell interactions in human AML bone marrow

This comprehensive spatial map of the AML bone marrow identified tripartite crosstalk between AML, macrophages, and T cells mediated by the Galectin-9 – CD44/TIM-3 axis as a key component of the immunosuppressive microenvironment.

M. van der Meulen, Emma S. Pool, A. Perzolli et al. · bioRxiv · 0 citations