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Neuronal activity-regulated histone demethylase KDM7A controls hippocampal gene expression and behavior.
It is shown that KDM7A is required for the proper transcriptional regulation of genes implicated in neuronal physiology and synaptic plasticity and that KDM7A-deficient mice display hyperlocomotion, reduced anxiety-like behavior, decreased sensitivity to pro-epileptic agents, and task-dependent changes in cognitive per...
KAT3 Shuttling Between Neuronal Identity and Activity-Dependent Plasticity Programs Drives Large-Scale Chromatin Remodeling
It is shown that neuronal activation triggers genome-wide redistribution of CBP and p300 in hippocampal neurons, and KAT3 redistribution is identified as a key mechanism coupling neuronal activity to large-scale chromatin remodeling.