Author

S. Paidesetty

2 papers indexed here

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Sep 2026

Rational design and synthesis of sulfonamide-substituted coumarinyl-imidazolone hybrids against multidrug-resistant microbial strains: computational and biological evaluation studies.

AIM The longstanding use of sulfonamides has contributed to the emergence of multidrug-resistant (MDR) pathogens, posing a major challenge to antimicrobial therapy worldwide. In response, a series of sulfonamide-linked coumarinyl-imidazolone derivatives (6a-t) were rationally designed and synthesized to identify potent...

Preetesh Kumar Panda, S. Paidesetty, Alaka Sahoo et al. · Future Medicinal Chemistry · 0 citations

Open access Sep 2026

All-atoms MD simulations study of newly designed ciprofloxacin derivatives as potential bacterial DHPS and DNA gyrase inhibitors

A series of ciprofloxacin-sulfonamide hybrid molecules was designed, in which each pharmacophore retains its established mechanism of action and CIS4, CIS5, and CIS12 emerged as the most promising dual-target inhibitor of bacterial DHPS and DNA gyrase.

Chita Ranjan Sahoo, Madhusmita Rout, S. Paidesetty et al. · Frontiers in Bioinformatics · 0 citations