Author

S. Pappatà

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Open access Oct 2026

Association Between Gray Matter Microstructure and Glucose Metabolism in Older Adults With Cognitive Decline: A Multimodal Imaging Study

Cortical glucose hypometabolism is a well‐established early marker of neurodegeneration in dementia, mainly reflecting neuronal and synaptic dysfunction. Its relationship with underlying microstructural alterations remains unclear. Here, we combined multi‐shell diffusion microstructural and [18F]‐FDG PET data to invest...

A. Canna, Alessandro Pasquale De Rosa, Emanuele Nicolai et al. · Human Brain Mapping · 0 citations

Open access Sep 2026

30. Brain hypometabolism and disorganization domain as putative neuronal correlates in schizophrenia: a comparative head-to-head treatment-resistant vs. treatment-responsive schizophrenia PET study

Abstract Background About a third of schizophrenia patients are refractory to antipsychotics, a condition characterized by poor clinical and functional outcomes known as treatment-resistant schizophrenia (TRS). The disorganization domain may represent the leading factor in categorizing a schizophrenia patient as affect...

M. Ciccarelli, F. Iasevoli, A. Barone et al. · International Journal of Neu... · 0 citations

Open access Aug 2026

Regional brain metabolism and metabolic connectivity alterations in corticobasal syndrome assessed with [18F]FDG-PET

This first [18F]FDG-PET metabolic connectivity study in CBS demonstrates asymmetric and bilateral regional hypometabolism, widespread and lateralized network disconnection, and subcortical reorganization, and highlights metabolic connectivity as a sensitive marker of network-level alterations in neurodegenerative disea...

Matilde Nerattini, Andrea Leo, Valentina Bessi et al. · European Journal of Nuclear... · 0 citations