S. Parvez

Multifunctional Methotrexate-Laden Nanotherapy Modulates the Joint-Brain Axis and Attenuates Associated Neuroinflammation in an Experimental Model of Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by persistent synovial inflammation, cartilage erosion, and systemic manifestations, including cognitive and neuropsychiatric complications. Increasing evidence highlights the bidirectional interplay of the joint-brain axis between peripheral inflammati...

Extracellular vesicle-mediated drug resistance in cancer.

Drug resistance remains a major challenge to successful cancer treatment. Although cell-autonomous genetic, molecular, and cellular modifications have historically been linked to resistance, there is growing evidence that extracellular vesicles (EVs) can promote the intercellular transfer of resistance-associated compo...

Majoon-e-Boolis as a neurotherapeutic agent: cognitive and neuronal restoration in alzheimer’s disease model

A combination of Nrf-2 activator, kinetin and zinc provides neuroprotection through NLRP3-NF-ԟB signaling in traumatic brain injury.

It is concluded that kinetin and zinc, alone and their combination show neuroprotective effects in TBI by activating Nrf-2 anti-oxidant defence and inhibiting NLRP3-NF-ԟB pathways.