Active pharmacotherapy versus expectant management of patent ductus arteriosus in extremely preterm infants: a meta-analysis with trial sequential analysis.
OBJECTIVES To assess the effectiveness and safety of active pharmacotherapy for patent ductus arteriosus (PDA) initiated based on echocardiography-criteria versus expectant management in extremely preterm infants <29 w gestation in the first three weeks of life. STUDY DESIGN Systematic review with meta-analysis and t...