CYP2C19 and ABCB1 polymorphisms in patients of Chuvash ethnic group: assessment of clopidogrel resistance and associations with recurrent myocardial infarction
Background. The prevalence of clopidogrel resistance among patients with cardiovascular diseases (CVD) reaches 30–40 %, significantly increasing the risk of recurrent myocardial infarction (MI) and other thrombotic events. Genetic polymorphisms in CYP2C19 and ABCB1 account for up to 40 % of the variability in antipl...