Preparing for Next-Generation Vaccines: Breakthrough Invasive Pneumococcal Disease Patterns Post-PCV13 and Post-PPSV23 in Australia.
BACKGROUND Pneumococcal conjugate (PCV) and polysaccharide (PPSV) vaccines have reduced invasive pneumococcal disease (IPD) in Australia. We evaluated breakthrough IPD following PCV13 and PPSV23 immunization (2009-2023) to inform next-generation vaccine strategies. METHODS We analyzed laboratory-confirmed IPD cases f...