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Author

S. Petrescu

2 papers indexed here

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Open access Aug 2026

Niemann-Pick type C1 protein regulates epidermal growth factor receptor stability in hepatic cells and facilitates the early steps of Hepatitis B virus infection

Background Chronic Hepatitis B virus (HBV) infection affects more than 250 million individuals worldwide, causing up to 1 million deaths yearly. Despite the significant disease burden, no curative therapy against HBV is currently available. Accumulating evidence indicate a strong and complex relationship between HBV an...

Stefania Ariadna Stefan-Buzatoiu, Petruta-Ramona Alexandru Flintoaca, Mihaela-Olivia Dobrica et al. · 0 citations
Open access Jul 2026

A novel IL-1β reporter assay identifies tolcapone as a caspase-1 suppressor targeting pyroptosis in endotoxemia

Unconventional protein secretion mediated by gasdermin D (GSDMD) pores is essential for the release of pro-inflammatory cytokines such as interleukin-1β (IL-1β), a major driver of many inflammatory pathologies. Despite extensive investigation over the years, discovery of IL-1β secretion modulators has been hindered by...

G. Chirițoiu, S. Ghenea, Gheorghita Isvoranu et al. · 0 citations

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