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Author

S. Polo-Alonso

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Open access Jul 2026

Genetic trade-offs in fertility and longevity explain the maintenance of disease-associated alleles in humans

By analysing genome-wide data across 62 diseases, longevity and fertility, it is shown that disease-risk alleles are generally associated with reduced longevity and increased fertility, while alleles that increase both fertility and disease risk have been favoured by natural selection.

Eva Brigos-Barril, Claudia Vasallo, X. Farré et al. · 2 citations
Jul 2026

Sleep-Related and Chronobiology Traits and Health-Related Phenotypes: A Phenome-Wide Mendelian Randomisation Study.

Findings indicate that genetically determined short sleep duration and insomnia symptoms are associated with mental and neurological problems, cardiovascular disease and musculoskeletal disorders, suggesting a potentially preventive, causal role of healthy sleeping patterns on chronic disease.

Marta H Hernandez, C. Lassale, A. Camps-Vilaró et al. · 0 citations

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