Controlling protein localization through chemical biology tools is essential for mechanistic interrogations, functional perturbations, and therapeutic development. While existing tools cover a wide range of applications, no single approach simultaneously enables inducible trapping, controlled release, and visualization...
W. Beyers, Sarah E. Plutkis, Kathryn R. Butcher et al.· bioRxiv· 0 citations
Synaptic vesicle cycling, if not properly constrained, can result in excessive neurotransmitter release and subsequent neural pathology. Rab GTPases orchestrate synaptic vesicle trafficking through GTP-dependent interactions with effector proteins, but the restraining mechanism of these interactions is unknown. Here we...
Dušan Garić, Jonathan G. Murphy, B. J. Teubner et al.· bioRxiv· 0 citations
Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma. Alveolar RMS (ARMS) has a poor prognosis and is driven by either t(2;13)(q35;q14) or t(1;13)(p36;q14) translocations resulting in the PAX3::FOXO1 (P3F) and PAX7::FOXO1 (P7F) fusion oncoproteins, respectively. Current in vivo model systems fail t...
Bradley T. Stevens, Yang E. Zhang, Matthew R. Garcia et al.· Cancer Research· 0 citations
De deleting Reg-1 has cell- and non-cell-autonomous benefits, nominating Reg-1 KO B7-H3-CAR T cells as a promising cell product for early-phase clinical testing in patients with solid tumors.
A. Adeshakin, Hao Shi, S. Perry et al.· Cell Reports Medicine· 0 citations
The authors identify a binding site on the Sonic Hedgehog signaling protein Smoothened for the allosteric regulator arachidonic acid (AA) and show that its disruption attenuates SHH- and sterol-stimulated SMO induction.
M. Dillard, Christina A. Daly, Rojalin Pradhan et al.· Nature Communications· 0 citations
Synaptic vesicle cycling, if not properly constrained, can result in excessive neurotransmitter release and subsequent neural pathology. Rab GTPases orchestrate synaptic vesicle trafficking through GTP-dependent interactions with effector proteins, but the restraining mechanism of these interactions is unknown. Here we...
Dušan Garić, Jonathan G. Murphy, B. J. Teubner et al.· bioRxiv· 0 citations
The study depicts an epigenetic polarity governing Treg-mediated immune tolerance, highlighting a fundamental asymmetry at the epigenetic level that differentially regulates Treg and conventional T cells.
Wenjun Huang, Yongqiang Feng, Jun Li et al.· Journal of Immunology· 0 citations
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