Open access
Jul 2026
Identifying endogenous substrates of the 26S proteasome through site-specific photocrosslinking
Genetic code expansion is used to introduce a photo-crosslinkable unnatural amino acid into the yeast 26S proteasome and capture cellular protein substrates as they translocate through the proteasomal ATPase motor, representing an exciting avenue for probing the landscape of proteasomal substrates and its changes in re...
S. Restrepo, Andreas Martin
· bioRxiv · 0 citations