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Review Aug 2026

Is extensive macular atrophy with pseudodrusen a variant of age-related macular degeneration? New insights from the first multiethnic, multicentreU.S. cohort.

OBJECTIVE To characterize the long-term clinical and multimodal imaging (MMI) features of extensive macular atrophy with pseudodrusen (EMAP) in a U.S. COHORT DESIGN Multicentre retrospective case series. PARTICIPANTS Patients diagnosed with EMAP between 2015 and 2025. METHODS Clinical records and MMI-including...

Alessandro Feo, Alberto Quarta, P. Ramtohul et al. · 1 citation
Review Open access Sep 2026

From Intermediate AMD to Geographic Atrophy: Biomarkers, Endpoints, and a Roadmap for Next-Generation Clinical Trials.

Age-related macular degeneration (AMD) is a leading cause of irreversible legal blindness worldwide. Treatments exist for late-stage AMD, but none exists for the intermediate stage (iAMD), which precedes significant vision loss. A therapy tested in iAMD would aim to prevent or slow progression to late-stage disease, me...

Alessandro Berni, P. Rosenfeld, D. Bacherini et al. · 0 citations
Review Sep 2026

Ultra-Widefield OCT Mapping of Foveal and Optic Nerve Head Topography Within Posterior Staphyloma in Pathologic Myopia.

OBJECTIVE To define the spatial relationship between the fovea and optic nerve head (ONH), and to evaluate their associations with foveal complications and peripapillary atrophy in posterior staphyloma. DESIGN Cross-sectional observational case series. PARTICIPANTS Eyes with pathologic myopia and posterior staphylo...

Alberto Quarta, P. Forte, Shinichiro Chujo et al. · 0 citations
Review Open access Aug 2026

Macular atrophy in neovascular age-related macular degeneration: Prevalence, risk factors, imaging features, and clinical implications.

Macular atrophy (MA) is a major cause of long-term visual decline in neovascular age-related macular degeneration (nAMD), despite the ability of anti-vascular endothelial growth factor (anti-VEGF) therapy to control exudation. We summarize current evidence on the definition, epidemiology, risk factors, imaging features...

Xue-Nan Zhuang, Chiara Olivieri, G. Neri et al. · 0 citations

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