Prostate-specific membrane antigen is a transmembrane glycoprotein that is highly specific and overexpressed in prostate cancer cells, making it an effective target for theranostics. Despite significant progress in recent years with prostate-specific membrane antigen-targeting radiopharmaceutical therapies that show pr...
Yang Wang, Jane McKenzie, S. Sandhu· Journal of Nuclear Medicine· 1 citation
StrainSpy, a statistical algorithm that jointly captures strain variations and replacement across longitudinal and multi-cohort studies without predefined thresholds, and machine learning models built on StrainSpy-selected features matched the predictive accuracy of abundance-based approaches, whilst avoiding the confo...
S. Mallawaarachchi, Kshitij Tandon, Nikhil Rajan et al.· bioRxiv· 0 citations
Accurate identification of cell types and states is essential for reliable single-cell RNA-sequencing analyses, yet current methods remain sensitive to continuous biological states, data preprocessing choices, and reference selection. Here we present ClustoCell, a reference-free method that resolves cell identity using...
Abbas Salavaty, M. Foroutan, N. Pretel et al.· bioRxiv· 0 citations
Bone metastases showed marked suppression of tumor-intrinsic type I interferon (IFN-I) signaling and loss of antigen presentation, features that were strongly associated with reduced bone metastasis-free survival and could inform precision therapeutic strategies for PCa.
Katie L. Owen, L. Gearing, B. Niranjan et al.· Cancer Research· 0 citations
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