Highlights What are the main findings? Redox regulation is dynamically coordinated with cell-cycle progression through phase-specific changes in H2O2 generation, sensing, buffering, and resolution. MnSOD, peroxiredoxins, Nrf2/HO-1/NQO1, glutathione, glutaredoxins, GPXs, and the thioredoxin system perform complementary...
R. Patwardhan, S. Morjaria, G. Nandi et al.· Cells· 0 citations
Chemoresistance remains a major barrier in non-small cell lung cancer (NSCLC) therapy. Glutathione reductase (GSR), a central regulator of glutathione redox homeostasis, has been implicated in tumor survival, yet its role in non-small cell lung cancer (NSCLC) chemoresistance remains unclear. We demonstrated that GSR is...
G. Panigrahi, Khushboo A Gandhi, Amisha Joshi et al.· Free Radical Biology & Medic...· 0 citations
It is shown that PRDX6 depletion enhances radiosensitivity in A549 lung cancer cells, and the underlying drivers of ferroptosis sensitivity in the PRDX6 background are identified.
Debojyoti Pal, R. Patwardhan, S. Sandur· Journal of Proteome Research· 0 citations
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