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Author

S. Sasidharan

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Review Aug 2026

Decoding Context-Dependent Sirtuin Pharmacology in Cancer: Metabolic-Epigenetic Switches and Precision Therapeutic Targeting.

A SIRT context code is defined in which NAD+ availability and compartmentalization, subcellular localization, PTM state, chromatin occupancy, oncogenic genotype, cell lineage, and tumor microenvironment jointly determine sirtuin output, arguing that successful sirtuin pharmacology will require context matching rather t...

Abdelwahab Aly, Zhi-Qing Tan, S. Sasidharan et al. · 0 citations

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