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S. Schattgen

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Open access Oct 2026

A pro-inflammatory effector-memory T cell program links peripheral EBV priming to CNS autoimmunity

T and B cell–mediated immunosurveillance of the central nervous system (CNS) can become maladaptive in multiple sclerosis (MS). Epstein–Barr virus (EBV) is a likely driver of MS, yet how exactly EBV-specific T cells contribute remains unclear. We generated an antigen-resolved atlas of blood and cerebrospinal fluid (CSF...

N. Kristensen, T. Tsaktanis, S. Frischholz et al. · 0 citations
Open access Sep 2026

Uneven TCR chain pairing constraints govern epitope recognition.

Combinatorial pairing of independently recombined T cell receptor (TCR) α- and β-chains is central to diversifying the TCR repertoire. Although sequence motifs in one chain correlate with epitope recognition, the extent to which a single chain dictates specificity remains unclear. Here, we systematically tested TCR cha...

Anastasia A. Minervina, M. Pogorelyy, K. Mayer-Blackwell et al. · 0 citations
Open access Aug 2026

Cytomegalovirus Modulation of CD8 T Cell Phenotype and Function in People Living with HIV-1

A subset of CMV-positive individuals with a marked expansion of CMV-specific CD8 T cells associated with markers of poor HIV-1 control are observed, which suggests an inappropriately elderly immune tone phenotype with HIV-1-CMV co-infection.

Brandi L. Clark, E. Allen, S. Schattgen et al. · 0 citations

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