T and B cell–mediated immunosurveillance of the central nervous system (CNS) can become maladaptive in multiple sclerosis (MS). Epstein–Barr virus (EBV) is a likely driver of MS, yet how exactly EBV-specific T cells contribute remains unclear. We generated an antigen-resolved atlas of blood and cerebrospinal fluid (CSF...
N. Kristensen, T. Tsaktanis, S. Frischholz et al.· bioRxiv· 0 citations
Combinatorial pairing of independently recombined T cell receptor (TCR) α- and β-chains is central to diversifying the TCR repertoire. Although sequence motifs in one chain correlate with epitope recognition, the extent to which a single chain dictates specificity remains unclear. Here, we systematically tested TCR cha...
Anastasia A. Minervina, M. Pogorelyy, K. Mayer-Blackwell et al.· Science· 0 citations
A subset of CMV-positive individuals with a marked expansion of CMV-specific CD8 T cells associated with markers of poor HIV-1 control are observed, which suggests an inappropriately elderly immune tone phenotype with HIV-1-CMV co-infection.
Brandi L. Clark, E. Allen, S. Schattgen et al.· Journal of the Pediatric Inf...· 0 citations
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