S. Schemmert

α‐Synuclein Aggregate‐Disassembling Compounds Prolong Survival in a Mouse Model of Parkinson's Disease

Pathological aggregation of α‐synuclein drives neuronal loss in Parkinson's disease. We therefore tested two optimized all‐d‐peptides, SVD‐17 and SVD‐1a, alongside the prototype SVD‐1. Surface plasmon resonance revealed that SVD‐17 binds monomeric α‐synuclein with a nanomolar KD of 1.09 nM. In vitro, SVD‐17 and SVD‐1a...