Author

S. Scheres

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Open access Oct 2026

Templated paired helical filament formation and tau fold-dependent inclusion morphologies in primary neurons

Neurodegenerative tauopathies are characterized by the abnormal assembly of tau into amyloid filaments with distinct, disease-specific folds. These filaments are proposed to spread in a prion-like manner, thus underlying the progression of pathology in diseased brains. A prediction of this hypothesis is that tau filame...

Melissa Huang, S. Lövestam, Kimberly Ai Xian Cheam et al. · bioRxiv · 0 citations

Open access Sep 2026

De novo design of flexible protein interactions with GuideFlip

De novo design of protein binders requires a target structure. However, for flexible targets, such as intrinsically disordered proteins, this structure does not exist until the binder has stabilized the interaction. Such targets are therefore difficult for methods that separate structure generation from sequence design...

Kai Yi, Qing-Chao Chen, Dong-Qi Zhang et al. · bioRxiv · 0 citations

Jul 2026

DBMol: Design of High-Affinity, Target-Specific Small Molecules through Structure Prediction Models

DBMol substantially improves pocket coverage while maintaining molecular diversity over unconditional generation, and is competitive under held-out metrics despite the absence of reference-ligand supervision, which support the promise of structure prediction models as effective optimization signals for de novo molecula...

Yiming Qin, Kai Yi, M. Cretu et al. · arXiv.org · 0 citations