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Open access Sep 2026

Metabolic dysregulation linked to sickling tendency in sickle cell anemia independent of HbF.

Sickle cell disease (SCD) presents substantial interindividual clinical variability that remains only partially explained by genotype, fetal hemoglobin (HbF), and co-inherited alpha-thalassemia. We investigated whether endogenous metabolites modulate the sickling tendency, independently of HbF. We analyzed 368 steady-s...

S. van der Veen, A. Idrizovic, T. Sanavia et al. · 0 citations
Open access Dec 2025

Tissue Factor/Factor XIa Dual-activated Thrombin Generation is Able to Reliably Measure Thrombin Generation at All Hemophilia A Disease Severities

The standardized TF/FXIa dual-activated TGA represents a tool for assessing individual coagulation potential in hemophilia A and showed substantial variation in interindividual TG levels among patients with comparable FVIII activity levels.

T. W. van de Berg, Alexandra C. A. Heinzmann, S. Thomassen et al. · 0 citations

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