BACKGROUND
Brain metastases (BrM) are a major cause of cancer-related mortality. To successfully colonize the brain, cancer cells must acquire unique adaptations. We hypothesized that BrM, regardless of their primary tumor origin, share convergent molecular features enabling brain colonization while retaining tumor typ...
Marana Abboud, S. Sisoudiya, Benjamin Kaplan et al.· Neuro-Oncology· 0 citations
High tumor mutational burden (TMB-H), defined as ≥10 non-driver somatic mutations per mega base of genome sequenced (mut/Mb), and high microsatellite instability (MSI-H), which can lead to TMB-H, are both associated with response to the immunotherapy pembrolizumab. Data from the KEYNOTE-158 study demonstrated that the...
Wen-Jun Zhong, E. Dettman, Lei Zhang et al.· Pediatric Hematology & Oncol...· 0 citations
Abstract Background CYLD , a tumor suppressor gene encoding a deubiquitinase enzyme, regulates tumorigenesis via NF-κB signaling. CYLD mutations are linked to immune evasion and PD-L1 upregulation, particularly in virus-associated cancers. We evaluated CYLD alterations across cancers and their correlation with PD-L1 ex...
U. Dişel, S. Sisoudiya, S. Sivakumar et al.· Research Square· 0 citations
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