Author

S. Sivakumar

2 papers indexed here

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Open access Sep 2026

Association of high tumor mutational burden with brain metastases: Insights from a large-scale database analysis.

BACKGROUND Brain metastases (BrM) are a major cause of cancer-related mortality. To successfully colonize the brain, cancer cells must acquire unique adaptations. We hypothesized that BrM, regardless of their primary tumor origin, share convergent molecular features enabling brain colonization while retaining tumor typ...

Marana Abboud, S. Sisoudiya, Benjamin Kaplan et al. · Neuro-Oncology · 0 citations

Open access Sep 2026

CYLD Mutations, PD-L1 and HPV; A Pan-Cancer Landscape Analysis

Abstract Background CYLD , a tumor suppressor gene encoding a deubiquitinase enzyme, regulates tumorigenesis via NF-κB signaling. CYLD mutations are linked to immune evasion and PD-L1 upregulation, particularly in virus-associated cancers. We evaluated CYLD alterations across cancers and their correlation with PD-L1 ex...

U. Dişel, S. Sisoudiya, S. Sivakumar et al. · Research Square · 0 citations