805. Rapid Antidepressant-Like Effects of 5-MeO-DMT Require Both 5-HT1A and 5-HT2A Receptors
Abstract Background Recent clinical trials show that 5-MeO-DMT produces rapid antidepressant effects, yet the receptor mechanisms underlying these outcomes remain incompletely defined. Although 5-MeO-DMT is a high-affinity agonist at multiple serotonergic receptors, the relative contribution of 5-HT1A and 5-HT2A recept...