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Author

Sara Spadini

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Oct 2026

Growth factor polygenic disposition shapes associations of childhood adversity with gray matter and clinical profiles in depression: A two-cohort imaging-genetics study.

AIM Adverse childhood experiences (ACE) are associated with greater symptom severity and treatment resistance in major depressive disorder (MDD), but their effects vary markedly across individuals. Growth factor polygenic profiles may contribute to this differential susceptibility by influencing stress responsivity, ne...

T. Cazzella, L. Fortaner-Uyà, Marco Paolini et al. · 0 citations
Open access Jul 2026

CLOCK 3111T/C Polymorphism and Sex Moderate the Effect of Childhood Trauma on White Matter Microstructure in Bipolar Disorder

Background. Bipolar disorder (BD) is characterized by circadian rhythm disruptions, contributing to mood instability and recurrence. These rhythms are regulated by clock genes in the suprachiasmatic nucleus, including the CLOCK 3111T/C (rs1801260) polymorphism that has been linked to delayed sleep phase, insomnia, and...

F. Nozza, B. Bravi, L. Fortaner-Uyá et al. · 0 citations

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