S. Spicuglia

Epromoter 3D interaction-associated regulation in T-acute Lymphoblastic Leukemia

Background Promoters have been traditionally seen as contiguous gene-adjacent cis-regulatory elements. Yet, substantial studies corroborate that Epromoters (promoters with enhancer activity) engage in distal forms of gene regulation. Although in the three-dimensional (3D) space enhancer-promoter networks have been well...