Author

S. Supattapone

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Open access Sep 2026

PRNP mutations initially generate an alternatively misfolded PrP species that dissuades prion replication

Mutations in the PRNP gene, which encodes the prion protein (PrP), cause genetic prion disease. However, how PRNP mutations lead to spontaneous prion formation remains poorly understood. Building off the observation that expression of mutant bank vole PrP (BVPrP) in mice causes spontaneous prion disease, we sought to i...

Genki Amano, H. Arshad, Surabhi Mehra et al. · bioRxiv · 0 citations

Open access Aug 2026

Glycogen Synthase Kinase-3β Regulates Cellular Prion Protein Levels

The results reveal that GSK-3β activity controls PrPC levels in living cells, revealing a novel regulatory mechanism and promising therapeutic target.

Kathryn S. Beauchemin, Anna M. Schmoker, J. Watts et al. · bioRxiv · 0 citations

Open access Aug 2026

A Unique Platform to Study the Dynamic Process of Prion Formation

Findings establish 7-HCAA as a site-specific and sensitive probe of local PrP conformation as a site-specific and sensitive probe of local PrP conformation and suggest a new strategy for studying conformational dynamics in amyloid-forming proteins.

Jessica de Alcantara Ferreira, Daniel J. Walsh, Evelyn M. Turnbaugh et al. · Biochemistry · 0 citations