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S. Synowsky

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Open access Sep 2026

A self-limiting dimeric TIR effector specialised for type III CRISPR-mediated immunity

Antiviral defence systems frequently utilise cyclic nucleotide second messengers. A prominent example is the type III CRISPR-Cas system, which generates cyclic oligoadenylates (cOA) on detecting viral RNA. cOA molecules can bind and activate a wide range of effectors to provide antiviral defence. In both prokaryotes an...

Yu Sun, Stephen McMahon, S. Synowsky et al. · 0 citations

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