IL-22 promotes the establishment of chronic gammaherpesvirus infection by supporting the germinal center response
Gammaherpesviruses, including human Epstein-Barr Virus (EBV) and Kaposi’s Sarcoma-associated Herpesvirus (KSHV), establish lifelong latent infections that contribute to multiple cancers and Multiple Sclerosis. These viruses colonize naïve B cells and drive a robust, polyclonal germinal center response to expand the lat...