Production and characterization of a functional anti-mouse PD-1 single-chain variable fragment (scFv) expressed from Bifidobacterium longum 105A.
Bifidobacterium species preferentially accumulate in solid tumors and have emerged as a promising platform for localized production of therapeutic molecules within the tumor microenvironment. In this study, we constructed a recombinant B. longum strain capable of secreting an anti-mouse programmed cell death-1 (PD-1) s...