Author

S. Temple

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Open access Oct 2026

Multi-omic profiling of 85 iPSC lines from familial dementia reveals cellular diversity and regulators of organoid development.

Systematic molecular characterization of human induced pluripotent stem cell (iPSC) lines carrying disease-associated mutations is needed to distinguish disease-related biology from variation in cell state, genomic integrity, and genome-editing history, yet such systematic characterization is uncommon. Here, we profile...

Le Qi, T. Bertucci, Susan Borden et al. · Neuron · 0 citations

Open access Sep 2026

MAPT regulates autophagic-lysosomal function and phagocytosis in human microglia

Using isogenic human induced pluripotent stem cell-derived microglia carrying the pathogenic MAPT IVS10+16 mutation, tau is identified as a regulator of microglial lysosomal function and degradative capacity is identified as a modifiable component of the microglial response to tau pathology.

Kylie J. Schache, Rui Zhang, Audrey Street et al. · bioRxiv · 0 citations

Open access Sep 2026

Large-scale single-molecule analysis of tau proteoforms

Iterative Mapping of proteoforms provides insights into proteoform complexity at the single-molecule level, with implications for understanding protein regulation in neurodegenerative diseases and beyond.

James Joly, V. Budamagunta, Zheng-Jian Zhang et al. · Nature Methods · 1 citation