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S. Thakral

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Open access Sep 2026

DEVELOPMENT, CHARACTERIZATION AND OPTIMIZATION OF DOLUTEGRAVIR SOLID DISPERSIONS USING PEG 6000 AND PVP K30: COMPARATIVE PROCESSING, FACTORIAL DESIGN AND TABLET DEVELOPMENT

Background: Dolutegravir (DTG) is a potent HIV-1 integrase inhibitor with poor aqueous solubility, which can limit its dissolution and oral absorption. Objective: To develop and optimize dolutegravir solid dispersions using hydrophilic carriers for enhancement of solubility and dissolution. Methods: Solid dispersions w...

Krupaben Pravinbhai Patel, S. Thakral · 0 citations

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