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S. Tirendi

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Open access Jul 2026

Amphiphilic Semisynthetic Triterpenoids Impair Survival Pathways and Suppress Clonogenic Growth in Multidrug-Resistant High-Risk Neuroblastoma

Functional studies revealed that the ursolic acid derivative 7 induces complete suppression of clonogenic growth at low micromolar concentrations in both HTLA ER and parental HTLA 230 NB cells, suggesting that compound 7 could kill cancer cells via a non-apoptotic, bioenergetic collapse mechanism.

S. Alfei, C. Domenicotti, S. Tirendi et al. · 0 citations

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