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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

S. Vanharanta

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Open access Aug 2026

Oriented binding of transcription factors to nucleosomes remodels chromatin at human promoters.

Transcription factors (TFs) can access nucleosomes via five distinct modes: gyre-spanning, periodic-binding, dyad-binding, and end-binding modes as well as an oriented binding mode, where the TF binding motif shows orientational preference relative to the nucleosome. Here, we report the first structure of an oriented T...

Tianyi Xiao, C. Crowe-McAuliffe, M. Ochmann et al. · 0 citations
Open access Sep 2026

BCL-XL dependence is a subtype agnostic actionable feature of difficult-to-treat kidney cancers

BCL-X L is a BCL-2 family anti-apoptotic protein that functions as a targetable dependency in clear cell Renal Cell Carcinoma (ccRCC), the most common form of adult kidney cancer. However, the mechanisms driving this dependence are unclear. Moreover, although significant strides have been made in managing ccRCC,...

Tupa Basuroy, Treg M. Grubb, Ananthan Sadagopan et al. · 0 citations

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