Increased mtDNA Polymorphism Level and Defective Mitophagy are Associated With Proinflammatory Activation in THP-1-Based Cybrids.
BACKGROUND Mitochondria play a key role in the regulation of inflammatory processes. It is well established that mitochondria contain their own mitochondrial DNA (mtDNA), which displays a substantially higher frequency of polymorphisms compared to the nuclear genome. To maintain mitochondrial functionality, cells emplo...