Dynamic Profiles of Serum Kisspeptin and DLK1 During GnRH Stimulation in Central Precocious Puberty and Premature Thelarche.
BACKGROUND The neuropeptides kisspeptin and Delta-like 1 homolog (DLK1) regulate pubertal timing by activating and inhibiting the hypothalamic-pituitary-gonadal (HPG) axis, respectively. Given these opposing regulatory roles, quantifying serum kisspeptin and DLK1 levels during gonadotropin-releasing hormone (GnRH) stim...