Amyotrophic lateral sclerosis is a fatal neurodegenerative disease increasingly linked to T cell responses, although the mechanisms driving T cell activation and disease progression remain unclear. Here we used single-cell RNA and T cell receptor sequencing, longitudinal immune profiling and imaging flow cytometry to i...
Zhen-Zhen Chen, Jannika Mansikkaviita, Christina Seitz et al.· Nature Medicine· 0 citations
Abstract Plasma cardiac troponin T (cTnT) is widely used as a marker of myocardial injury, yet recent studies suggest elevations in amyotrophic lateral sclerosis (ALS). Whether these elevations reflect disease-associated skeletal muscle remodelling remains unresolved. In this translational study, we analysed longitudin...
L. Öijerstedt, Jia-Ning Lin, Aditya Singh et al.· Brain Communications· 0 citations
Plasma and cerebrospinal fluid (CSF) protein biomarkers in amyotrophic lateral sclerosis (ALS) may provide insight into disease mechanisms and yield clinically useful biomarkers.
Lu Pan, C. Hou, Christina Seitz et al.· European Journal of Neurolog...· 0 citations
Cell-type enrichment analysis indicating a broad cellular origin of the circulating proteome, with contributions from nervous system cells, vascular cells, immune cells, and muscle cells, highlights the potential of plasma proteomics for clinically meaningful patient stratification in ALS.
I. Aksoylu, L. Azizi, L. OÌijerstedt et al.· medRxiv· 0 citations
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