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S. Zhuang

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Open access Oct 2026

Mechanosensitive HEG1-NOTCH1 signals governs endothelial cell function in the pathogenesis of pulmonary hypertension

Endothelial cells (ECs) adapted mechanosensitivity to flow shear-stress are critical for vascular homeostasis. HEG1 as an endothelial mechanosensitive gene exerts anti-hypertensive and atheroprotective effects, yet its regulation of pulmonary endothelial function for pulmonary hypertension (PH) pathogenesis and t...

L. Hu, J. Xu, Y. Ji et al. · 0 citations
Open access Sep 2026

HDAC4 drives ferroptosis and fibrosis by inhibiting Foxo3a-GPX4 axis during AKI–CKD progression

Histone deacetylase 4 (HDAC4) modifies both histone and non-histone proteins, but its role in the transition from acute kidney injury (AKI) to chronic kidney disease (CKD) remains unclear. Here, we investigated the function and mechanism of HDAC4 in ischemia-reperfusion (IR)-induced AKI-CKD progression using Tasquini...

Feng-Chen Shen, Lin Hu, Xin-Yu Du et al. · 0 citations

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