Review
Open access
Sep 2026
GNA15 as a regulator of tumor–immune crosstalk: oncogenic signaling, microenvironmental remodeling, and implications for targeted immunotherapy
GNA15 is a Gαq-family G protein whose physiological expression is largely restricted to hematopoietic cells. Nevertheless, aberrant upregulation has been reported in six histologically distinct malignancies, with elevated expression consistently associated with adverse clinical outcomes. Unlike the ubiquitously express...
Aarka Undar, Shweta Sunil Nambiar, Mukil Srivasan et al.
· Frontiers in Immunology · 0 citations