Author

Sabina Spagna

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Review Open access Oct 2026

Magnesium supplementation for anxiety and depression: a systematic review of clinical evidence and mechanistic insights

Magnesium is an essential cofactor in numerous enzymatic reactions regulating neuronal excitability, neurotransmission, and stress response. Deficiency has been linked to affective dysregulation through altered N-methyl-D-aspartate (NMDA) and γ-aminobutyric acid (GABA) signaling, impaired neuroplasticity, and activatio...

Lorenzo Campedelli, Andrea Cicoli, M. Lastretti et al. · Food Production, Processing... · 0 citations

Review Sep 2026

Lithium exposure and risk of dementia and Alzheimer's disease: A systematic review and meta-analysis.

BackgroundAlzheimer's disease (AD) is the most common cause of dementia, affecting over 55 million people worldwide with no established disease-modifying treatments. Lithium has emerged as a potential neuroprotective agent through multiple molecular mechanisms, and observational studies suggest reduced dementia risk am...

Lorenzo Campedelli, Andrea Cicoli, M. Lastretti et al. · Journal of Alzheimer's Disea... · 0 citations

Review Open access Jul 2026

The Gut–Brain Axis in Depression: A Systematic Review of Microbiota and Mental Health

Gut microbiota dysbiosis represents a biologically plausible mediator of depression pathophysiology, with a recurrent dysbiotic pattern, characterised by depletion of butyrate-producing taxa and enrichment of pro-inflammatory genera, showing emerging diagnostic and therapeutic potential.

Lorenzo Campedelli, Andrea Cicoli, M. Lastretti et al. · Swiss Archives of Neurology,... · 0 citations