Author

Sabine Schneider

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Open access Oct 2026

Structural basis of eIF4E recognition of synthetic mRNA 5′ cap analogues links cap architecture to affinity and biological activity

Eukaryotic mRNAs carry a 5′-terminal 7-methylguanosine (m7G) cap that is recognized by multiple cellular proteins and is essential for mRNA self-discrimination, stability, and translation. The eukaryotic translation initiation factor 4E (eIF4E) binds the 5′ cap and promotes recruitment of mRNAs to the ribosomal transla...

Sabine Schneider, Sarah Moreno, Moritz Thran et al. · bioRxiv · 0 citations

Open access Aug 2026

Selective oxidation and quantification of m5C in ribonucleosides and RNA in an epigenetic context

Selective modification of methylated bases in RNA and DNA is central to the field of epigenetics and furthermore fundamental for developing next-generation sequencing and liquid biopsy applications. While in DNA the detection and modification of 5-methylcytidine (5mdC) is fairly advanced, current strategies for detecti...

Kora Holschbach, T. Walter, Davide Guglielminotti et al. · RSC Chemical Biology · 0 citations

Review Open access Aug 2026

Unmasking the modified small non-coding RNome: detection strategies for RNA modifications

Current strategies for detecting and mapping RNA modifications in the small RNome include demodification-based sequencing approaches for heavily modified RNAs, targeted chemical and enzymatic methods for site-specific mapping, and emerging direct RNA sequencing technologies that allow analysis of native molecules witho...

Bennett Henzeler, Kathrin Halter, Özge Simsir et al. · Biological chemistry · 0 citations